Czech Academy of Sciences

Institute of Microbiology, v.v.i.

 

LABORATORY OF MOLECULAR BIOLOGY OF BACTERIAL PATHOGENS

  

Head: Peter Šebo, PhD.

 

 

 

Main research activities

Structure-function relationships underlying the molecular mechanisms of membrane penetration and action of bacterial protein toxins.

Use of bacterial protein toxins as immunogens and vectors for delivery of foreign antigens and induction of specific immune responses against infectious agents and tumors.

Experimental models

The RTX adenylate cyclase toxin (ACT) of the whooping cough agent Bordetella pertussis.

The novel RTX pore-forming toxin RtxA of the pediatric facultative pathogen Kingella kingae.